Properties

• Target:
• mGlu1 Receptor

• CAS Number:
• 1623101-11-0

• Chemical Name:
• 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide

• Storage:
• Store at -20°C

• Molecular Formula:
• C20H10Cl3N3O3

• Molecular Weight:
• 446.67

• Soluble:
• DMSO

Description

• Description:
• Positive allosteric modulator (PAM) of mGlu1 receptors

Biological Activity

• Biological Activity:
• VU 0483605 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGluR1). In mGlu1 mutant cell models of schizophrenia, it can potentiate the decreased glutamate-induced calcium response.