Properties

• Target:
• Hedgehog Signaling

• CAS Number:
• 4449-51-8

• Chemical Name:
• (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

• Storage:
• Desiccate at -20°C

• Molecular Formula:
• C27H41NO2

• Molecular Weight (kDa):
• 411.63

• Soluble:
• Ethanol

Description

• Description:
• Hedgehog (Hh) signaling inhibitor

Biological Activity

• Biological Activity:
• Cyclopamine, a naturally occuring chemical, is a hedgehog (Hh) signaling inhibitor. It exhibits teratogenic and anticancer effects in vivo. By interaction with the Hh signaling protein smoothened, Cyclopamine can specifily inhibit the Hh pathway.