G Protein Independent Functional Assays
Creative Biolabs provides G protein independent functional assay services based on multiple assay formats to accelerate GPCR research and drug development. We can further help speed up your drug discovery by combining high-throughput technology.
Introduction of G Protein Independent Functional Assays
G protein-coupled receptors (GPCRs) play an important role in health and disease. They represent the largest family of druggable targets. The development of GPCR assays has always been the focus of drug discovery research. Efforts have been made to develop functional assays to provide more comprehensive information for GPCR drug discovery. Choosing the right assay is important for the early stage of drug discovery.
As the activation of G protein by GPCRs is the basis of transmembrane signal transduction, early GPCR functional assays mainly depend on G proteins. With further understanding of GPCR signal transduction, many G protein independent assays have been developed to detect GPCR activity. These assays can also be combined with high-throughput technology, automation technology, label-free technology and other technologies to provide more additional valuable information for drug development and improve the success rate in drug discovery.
Figure 1. Examples of G protein- and β-arrestin-mediated downstream signaling pathways on GPCRs. (Bologna Z, et al., 2017)
G Protein Independent Functional Assay Services
We offer our customers with a comprehensive selection of G protein independent functional assays to meet their different research needs.
|GPCR internalization assay
|β-arrestin recruitment assay
|Label free assay
|GPCR dimerization assay
- Customized services based on multiple assays formats.
- One-stop solutions for all your problems.
- High-quality and reliable results under strict quality control conditions.
- Fast turnaround time and competitive price.
Creative Biolabs provides our customers with customized G protein independent functional assay services in a time- and cost-effective manner. Our experts will work closely with you to fully meet your requirements.
If you are interested in our services or have any specific needs, please feel free to contact us for more details.
- Bologna Z, et al. Biased G protein-coupled receptor signaling: new player in modulating physiology and pathology. Biomolecules & therapeutics, 2017, 25(1): 12.
- Zhang R & Xie X. Tools for GPCR drug discovery. Acta Pharmacologica Sinica, 2012, 33(3): 372-384.