GPCRs Protein-Based Solutions
G protein-coupled receptors (GPCRs), a superfamily of integral membrane proteins in eukaryotic cells, are vital in a wide range of physiological functions. They can modulate homeostasis, metabolism, sensory perception and adaptation of neurotransmission. Their involvement in various diseases makes them the largest class of therapeutic targets. A better understanding of the structure and function of GPCRs can provide great potential for drug development.
Creative Biolabs provides comprehensive and professional protein-based solutions for GPCR research and drug development to help our customers facilitate their cutting-edge projects. We offer customized services based on a complete set of protein assays.
It is indispensable to establish a robust, efficient and reliable expression system to obtain stable GPCRs in sufficient quantities for various downstream applications. Based on various strategies and technique platforms, we can select the most suitable expression system and provide customized services tailored to specific requirements of our customers.
GPCR Solubilization and Stabilization
The intrinsic instability in aqueous solutions and the hydrophobic nature of GPCRs make it difficult to isolate functional GPCRs from membrane without compromising the structural and functional integrity of the protein. With our unreserved services and best efforts, we can help our customers find the most suitable strategies for GPCR solubilization and stabilization.
GPCRs always need some robust purification protocol prior to further studies. The most important thing is to ensure that the experimental conditions can maintain the active state of GPCRs. Whether you need labeled or untagged GPCRs, single protein or GPCR complex, small-scale or large-scale purification, we have established an unparalleled platform to provide the most reliable services and meet your specific requirements.
Protein Engineering of GPCR
Protein engineering is the process of developing useful or valuable unnatural proteins through rational protein design or directed evolution. It plays a central role to design and construct GPCRs with desired properties and functions. We have long-term devoted to protein engineering of GPCRs. We are capable to provide customized services to help our customers accelerate their project process.
Protein identification is an important work in biological research, disease diagnosis, and biopharmaceutics, which can characterize the basic properties of proteins. The identification of GPCRs can provide valuable insights for further understanding of their basic properties and the regulation of their biological processes. We can enable GPCR identification in gel band, gel spot, solution or protein mixture.
Protein Labeling of GPCR
Protein labeling is essential to study the abundance, distribution, structure, conformational changes, protein interaction, internalization process, and post-translational modification of GPCRs. It can also help gain mechanistic insight of GPCR functions. We can provide our customers with the widest labeling options and help choose the most appropriate labeling strategy to fully meet their specific needs of downstream applications.
Protein Tagging of GPCR
Protein tagging is an important aspect of protein analysis. Various protein tags with different functions have been successively developed and applied in various applications. Protein tagging can promote the extensive study of GPCR structure and function. We can help our customers choose the best tag and the appropriate labeling strategies for their specific applications.
GPCR Peptide Library
Peptide library is of great significance to understand the receptor-ligand interactions and identify ligands at orphan GPCRs for the development of novel GPCR-targeted drugs. We have developed a variety of technical platforms to provide multiple types of peptide libraries for different requirements of GPCR research and drug development.
Discover Our Techniques
We have developed a variety of advanced GPCR technology platforms. Our experienced scientific team has always been committed to providing our customers with professional services and reliable results with fast turnaround time. We will be a reliable partner in your GPCR research and drug development process.
Creative Biolabs also has a scientific team with professional proteomics technology and structural biology, which can provide customized solutions that best meet your requirements.
If you are interested in our services or have any specific needs, please feel free to contact us for more details.