GPCR Preclinical Drug Development
G protein-coupled receptors (GPCRs) play an important role in multiple diseases. They represent the most leading family of validated therapeutic targets in pharmaceutical development. In recent years, a large number of newly discovered targets have provided new impetus for GPCR drug development, while preclinical drug development links drug discovery to the initiation of human clinical trials.
Creative Biolabs provides professional and high-quality preclinical services to help our customers accelerate their GPCR drug development process. With innovative technologies and advance platforms, our experienced scientists can offer customized services and one-stop solutions to meet specific requirements in a timely and cost-effective manner. We will work closely with our customers to help them overcome challenges and move from concept to clinic more quickly and efficiently.
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Preclinical Toxicological Evaluation
Preclinical toxicological evaluation is a necessary process to test any substance as a drug on animals at various levels before clinical use in order to ensure complete human safety in each and every aspect. Toxicological data must undergo an evaluation of reliability to minimize the chance of a failed clinical trial. We are proud to offer powerful and reliable services for both in vitro and in vivo preclinical toxicological evaluation of drugs targeting GPCRs.
Preclinical Pharmacological Evaluation
Preclinical pharmacological evaluation involves the detailed assessment of both the in vitro and in vivo drug-like properties. It is important to perform such evaluation in experimental systems simulating clinically relevant human conditions. We provide a full range of pharmacological evaluation services, from pharmacodynamics, pharmacokinetics to safety pharmacology, to help transform findings from the laboratory and basic science into the clinical practice.
Drug metabolism and pharmacokinetics (DMPK) is the process to evaluate half-life, bioavailability, clearance, metabolic profile, and other properties of new drugs. DMPK studies combined with the analysis of absorption, distribution, metabolism and excretion (ADME) can provide the basis for screening compounds with desirable properties that are likely to proceed for subsequent drug development. We provide a full range of services for ADME/DMPK assays and analysis to accelerate GPCR drug development.
Stability testing in drug development aims to provide evidence on how the quality of a drug substance or product and its packaging varies with time under the influence of various environmental factors, including temperature, humidity, and light. Prior to the approval of new products, it has become a legal requirement to provide data the regulatory agencies with certain types of stability test data. We provide comprehensive stability testing of new drug substances targeting GPCRs.
The use of animal models has improved our understanding of diseases and ensured the safety of drugs before entering the clinical phase with human subjects. Each model is useful in certain types of studies or phases of drug development. The selection of the appropriate animal models for preclinical studies is one of the most important steps. We are committed to providing a full range of high-quality animal models to accelerate GPCR drug discovery and development pipeline.
Bioanalysis in drug discovery and development generally refers to the quantitative measurement of a drug or their metabolites in biological fluids, such as blood, serum and tissue extracts. It is critical at every stage of drug discovery and development, and can provide valuable information for early clinical practice. We use our state-of-the-art analytical platform to provide a wide range of bioanalytical services integrated with our drug discovery and preclinical capabilities.
Preclinical Formulation Development
Preclinical formulation development aims to develop a stable, safety and acceptable formulation based on patient's needs. All pharmaceutical products need to be formulated to specific dosage forms before delivered to patients. It connects the discovery of new drug substances with the successful development of commercial drug products. We provide professional preclinical formulation development services for a wide range of product types and dosage forms to help our customers develop the optimal formulation that can precisely match their requirements.
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