Applications

• Applications:
• Western Blot (0.5-4 μg/mL)

Specification

• Description:
• CCR1 Rabbit Polyclonal Antibody is raised against synthetic peptide corresponding to residues surrounding amino acids 341 of human CCR1.

• Molecular Weight (kDa):
• 42 (Theoretical)

• Form:
• Liquid

• Storage Buffer:
• In PBS (30% glycerol, 0.5% BSA, 0.01% thimerosal)

• Storage:
• Short term storage: -20°C.
  Long term storage: -80°C.
  Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name:
• CCR1

• Gene Description:
• CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]