Applications

• Applications:
• Western Blot (1:100-1:500), Immunohistochemistry (1:50-1:100), Enzyme-Linked Immunoabsrbent Assay (1:1000)

Specification

• Description:
• CRY1 Rabbit Polyclonal Antibody is raised against synthetic peptide (conjugated with KLH) corresponding to the C-terminus of human CRY1.

• Form:
• Liquid

• Purification:
• Protein G purification

• Storage Buffer:
• In PBS (0.09% Sodium Azide)

• Storage:
• Short term storage: 4°C.
  Long term storage: -20°C or lower.
  Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name:
• CRY1

• Gene Description:
• CRY1 (Cryptochrome Circadian Regulator 1) is a protein coding gene. This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

• Protein Accession Number:
• NP_004066; Q16526