Applications

• Applications:
• Immunohistochemistry (1:50-1:100)

Specification

• Description:
• NPR1 Rabbit Polyclonal Antibody is raised against synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NPR1.

• Form:
• Liquid

• Purification:
• Protein G purification

• Storage Buffer:
• In PBS (0.09% Sodium Azide)

• Storage:
• Short term storage: 4°C.
  Long term storage: -20°C or lower.
  Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name:
• NPR1

• Gene Description:
• NPR1 (Natriuretic Peptide Receptor 1) is a Protein Coding gene. Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

• Protein Accession Number:
• NP_000697; P16066