Specification

• Cell Line:
• CHO-K1

• GPCR Family:
• Bradykinin Receptors

• Gene Name:
• BDKRB1

• Assay Target Class:
• GPCR

• GenBank Accession Number:
• NM_000710

• Assay Validated:
• Calcium Luminescence

• G-Alpha Natural Receptor:
• Gq/G11

• Second Messenger Release:
• Calcium flux

• Shipping Condition:
• Dry Ice

• Storage:
• Should be stored in liquid nitrogen immediately upon receipt.

• Therapeutic Area:
• Angiogenesis, Pain, Cardiovascular, Inflammation

Description

• We have different stable recombinant cell lines that express a variety of GPCRs for binding and functional assays.

Detailed Information

• CHO-K1/BDKRB1 is a stable recombinant human cell line expressing Bradykinin, B1 subtype (BDKRB1). Upon the stimulation of GPCR, calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. This cell line has been functionally validated and tested under variable conditions. It is amenable for use with calcium coupled ion channels and tyrosine kinase receptors