Applications

• Applications:
• Western Blot (0.3-1 μg/mL), Enzyme-Linked Immunoabsorbent Assay (1:4000)

Specification

• Description:
• GALR2 Goat Polyclonal Antibody is raised against a synthetic peptide corresponding to human GALR2.

• Molecular Weight (kDa):
• 41.7 (Theoretical)

• Form:
• Liquid

• Concentration:
• 0.5 mg/mL

• Sequence:
• C-RYPLHSRELRTPRN

• Purification:
• Antigen affinity purification

• Storage Buffer:
• In Tris saline, pH 7.3 (0.5% BSA, 0.02% Sodium Azide)

• Storage:
• Store at -20°C or lower.
  Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name:
• GALR2

• Gene Description:
• GALR2 (Galanin Receptor 2) is a Protein Coding gene. Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

• Protein Accession Number:
• NP_0.03848.1