GPCR Target Identification

GPCR Target Identification

For Research Use Only. Not For Clinical Use.

Creative Biolabs provides professional services and innovative technologies for GPCR target identification to help accelerate the drug development pipeline.

Introduction of GPCR Target Identification

Target identification refers to the process of identifying an efficacy biological target, such as protein or nucleic acid, whose activity can be modulated by small molecule drugs or biotherapeutics. It is the cornerstone of successful drug development. Techniques based on principles of biochemistry, genetics, computational biology, biophysics, or many other disciplines may be applied to target identification.

G protein-coupled receptors (GPCRs), a superfamily of transmembrane proteins, play an important role in a wide range of physiological processes. In terms of drug targets, they have been the most useful family of proteins. GPCRs have become targets of many commercial therapeutic drugs against a variety of diseases, and remain a primary focus of many drug discovery programs. In view of the fact that the emergence rate of new drugs targeting GPCRs in the market is decreasing, there is a need to maintain high expectations for GPCR target identification.

GPCR Target IdentificationFigure 1. GPCR drug targets. (Hauser A S, et al., 2017)

Our Featured Services

We are proud to offer the most robust and reliable services for the identification of GPCR targets. Browse our featured services below or use our online inquiry form to get more information.

Multi-Omics-Based Target Identification

Omics-based approaches are broadly used to identify molecular targets for therapeutic development. We provide professional multi-omics-based target identification services based on genomics, proteomics, microbiomics, metabolomics, transcriptomics, and many other omics technologies.

Target Identification from Data Mining Approaches

Data mining uses statistical methods and computer tools to assist target identification. We provide data mining approaches, including proteomic data mining and chemogenomic data mining, to provide useful data and information for target identification in the omics era.

Genetic-Driven Druggable Target Identification

Systematic genetic association analysis of diseases and quantitative traits is a powerful approach to identify druggable targets. We provide genome-wide association studies (GWAS) to help infer drug targetable candidates.

Computational Approaches in Target Identification

Computational approaches have great potential to advance in silico drug discovery. We provide computational tools and databases that can acquire and analyze voluminous datasets, especially chemoinformatic tools, to provide reliable data outcomes for target identification.

CRISPR-Cas9 Screening

CRISPR-Cas9 screening is a powerful forward genetic screening tool to assess gene functions on the whole genome level. We provide efficient CRISPR-Cas9 screening services with high on-target specificity.

Target Deconvolution

Target deconvolution refers to the retrospective identification of molecular targets of small molecules that underlie an observed phenotypic response. We provide effective target deconvolution services to accelerate drug discovery.

Creative Biolabs provides customized GPCR target identification services to fully meet the requirements of our customers. Our experienced scientific team can offer tailored one-stop solutions in a high-quality, timely and cost-effective manner to help you achieve your goals.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.


  1. Hauser A S, et al. Trends in GPCR drug discovery: new agents, targets and indications. Nature reviews Drug discovery, 2017, 16(12): 829.
  2. Franco R, et al. Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators. Expert opinion on drug discovery, 2010, 5(4): 391-403.