ADME/DMPK Test of GPCRs
Creative Biolabs provides a full range of services for ADME/DMPK assays and analysis to accelerate GPCR drug development. We offer expertise and advanced technology to help our customers cope with increasing and unexpected challenges of time, quality and cost.
Introduction of ADME/DMPK
Drug metabolism and pharmacokinetics (DMPK) is the process to evaluate half-life, bioavailability, clearance, metabolic profile, and other properties of new drugs. It is an essential part of preclinical drug development to deal with safety and efficacy evaluation of drug candidates. Undesirable DMPK profile is the key reason for unwanted side effects and drug withdrawal.
DMPK studies combined with the analysis of absorption, distribution, metabolism and excretion (ADME) can provide the basis for screening compounds with desirable properties that are likely to proceed for subsequent drug development. Drug-drug interaction (DDI) can also be evaluated to reduce the risks and attrition due to the lack of efficacy and poor safety profiles.
Figure 1. Overview of the main tasks of DMPK support during the different phases of drug discovery. (Reichel A & Lienau P, 2015)
Our Featured Services
We are proud to offer powerful and reliable services for studying the metabolism and pharmacokinetics of your drug candidates. Browse our featured services below or use our online inquiry form to get more information.
We provide multiple formats of in vitro and in vivo ADME assays for identifying and evaluating the attributes of absorption, distribution, metabolism and excretion properties, so as to help de-risk drug candidates and improve project productivity. Our services include but are not limited to physicochemical properties, metabolic stability, drug distribution, permeability measurement, metabolite identification and profiling, excretion balance, and radioactivity sample analysis.
We provide comprehensive in vitro and in vivo DMPK analysis to assist in minimizing compound failure, optimize PK parameters, and assess the safety and efficacy of new drugs. Our services include but are not limited to PK modeling, mass balance studies, metabolite profiling, and tissue distribution.
We provide a range of drug-drug interaction assays to test the potential of drugs to inhibit or induce metabolic enzymes and drug transporters related to clinically relevant drug-drug interactions. Our services include but are not limited to cytochrome P450 induction and inhibition, UGT inhibition, reaction phenotyping, and transporter assays.
Creative Biolabs provides customized ADME/DMPK services and tailored one-stop solutions in a high-quality, timely and cost-effective manner. Our experienced scientific team will work closely with our customers to help them achieve their goals.
If you are interested in our services or have any specific needs, please feel free to contact us for more details.
- Reichel A & Lienau P. Pharmacokinetics in drug discovery: an exposure-centred approach to optimising and predicting drug efficacy and safety. New approaches to drug discovery. Springer, Cham, 2015: 235-260.
- Wan H. What ADME tests should be conducted for preclinical studies?. ADMET and DMPK, 2013, 1(3): 19-28.