Animal Models of GPCRs
Creative Biolabs are committed to providing a full range of high-quality animal models to accelerate GPCR drug discovery and development pipeline. We offer expertise and advanced technology to help our customers cope with increasing and unexpected challenges of time, quality and cost.
Introduction of Animal Models
In the past century, the use of animal models has improved our understanding of diseases and ensured the safety of drugs before entering the clinical phase with human subjects. There are a wide variety of animal models used in drug development, such as Drosophila, C. elegans, mice, rats, rabbits, dogs, cats and non-human primates. High-quality and validated animal models are critical for successful drug discovery and development. Because of the advantages and disadvantages of each model, they are useful in certain types of studies or phases of drug development.
Animal models can be roughly classified into four categories: induced or experimental models, spontaneous or natural models, negative or nonreactive models, and orphan models. The selection of the appropriate animal models for preclinical studies is one of the most important steps. Important factors, such as the appropriateness as an analog, the correlation to human trials, genetic uniformity, differences in drug response due to species difference, adaptability to experimental manipulation, ecological consequences, and ethical implications, need to be carefully considered.
Figure 1. In vivo imaging of G protein activity with cell implantation. (Takakura, et al., 2015)
List of Animal Species Provided by Creative Biolabs
Our Featured Services
Our experienced scientists can select the most appropriate animal model and the most reliable strategy for your drug candidates to address specific needs. Browse our featured services below or use our online inquiry form to get more information.
We provide a wide range of popular animal models, such as immunodeficient models and genetically engineered models, as useful tools to evaluate the efficacy and safety of drug candidates.
Our experts with years of experience in animal modeling can provide custom animal models to help our customers obtain the most relevant model for specific applications in drug development. Both Germ-free and SPF animal models are available.
We can provide induced animal models, spontaneous animal models and negative animal models of the following diseases.
Creative Biolabs has the ability to develop new animal models according to specific requirements. Our experienced scientific team will work closely with our customers to help them achieve their goals. We also provide in vivo assays to accelerate the progress of your drug development pipeline.
If you are interested in our animal models or have any specific needs, please feel free to contact us for more details.
References
- Takakura, et al. Cell-Based Assays and Animal Models for GPCR Drug Screening. G Protein-Coupled Receptor Screening Assays. Humana Press, New York, NY, 2015: 257-270.
- Greek R. Animal models in drug development. New Insights into Toxicity and Drug Testing. In Tech, Croatia/Europe, 2013: 123-52.