Preclinical Formulation Development of GPCRs

Preclinical Formulation Development of GPCRs

For Research Use Only. Not For Clinical Use.

CD BioSciences provides professional preclinical formulation development services for a wide range of product types and dosage forms. We offer expertise and advanced technology to help our customers develop the optimal formulation that can precisely match their requirements.

Introduction of Preclinical Formulation Development

Preclinical formulation development, which aims to develop a stable, safety and acceptable formulation based on patient's needs, is an essential component of drug development. It connects the discovery of new drug substances with the successful development of commercial drug products. Formulation development requires the determination of the most appropriate route to achieve effective drug delivery, and the optimization of the characteristics based on the understanding of the bioavailability and processing requirements of pharmaceutical products.

All pharmaceutical products need to be formulated to specific dosage forms, such as oral tablets, capsules, solutions, suspensions, gels, and injections, before delivered to patients. Different dosage forms may require different pharmaceutical technologies, which present technical challenges for formulation development. Therefore, preclinical formulation requires a deep understanding of various formulation parameters, chemical and physical characterization, toxicology, pharmacokinetics, and analytical techniques.

A schematic of a decision tree for a new chemical entity based on various physicochemical properties.Figure 1. A schematic of a decision tree for a new chemical entity based on various physicochemical properties. (Shah S M, et al., 2014)

Our Capabilities

We offer formulation development services for a variety of dosage forms, including but not limited to the following:

Formulation development services for various dosage forms – CD BioSciences

Our Featured Services

We provide comprehensive preclinical formulation development services to help our customers avoid failure that may lead to delay or suspension of preclinical drug development. Browse our featured services below or use our online inquiry form to get more information.

Preformulation Development

Preformulation development is the first step and the fundamental aspect before the rational development of a pharmaceutical formulations. We provide complete services for preformulation development to help our customers enhance the performance of their drug substances across a variety of dosage forms.

Formulation Development

Formulation development usually begins after the required minimum physicochemical characterization has been completed. We have robust experience and capabilities in formulation development. Our services cover a wide range of dosage forms and delivery technologies to meet different needs of our customers.

Comprehensive Evaluation Parameters

  • Solubility studies
  • Permeability
  • Stability
  • Availability
  • Purity
  • Hygroscopicity
  • Absorbance spectra
  • Solid state
  • Solvent
  • Drug-excipient compatibility
  • Organoleptic properties
  • Physicochemical properties

CD BioSciences provides our customers with customized preclinical formulation development and one stop solutions to meet their specific requirements with fast turnaround time and competitive price. Our experienced scientific team will work closely with our customers to help them achieve their goals.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

  1. Shah S M, et al. Preclinical formulations: insight, strategies, and practical considerations. Aaps Pharmscitech, 2014, 15(5): 1307-1323.
  2. Li P & Zhao L. Developing early formulations: practice and perspective. International Journal of Pharmaceutics, 2007, 341(1-2): 1-19.