GPCR Preclinical Pharmacological Evaluation

GPCR Preclinical Pharmacological Evaluation

For Research Use Only. Not For Clinical Use.

CD BioSciences provides professional services and innovative technologies for preclinical pharmacological evaluation to accelerate GPCR drug development.

Importance of Preclinical Pharmacology

Pharmacology is the study of drug actions at all levels. It involves the detailed assessment of both the in vitro and in vivo drug-like properties. Preclinical pharmacology is an essential element of the drug discovery and development process. It is important to perform preclinical pharmacological evaluation in experimental systems simulating clinically relevant human conditions. Preclinical pharmacological evaluation is not simply to prove the efficacy of drug candidates, it plays a critical role in transforming findings from the laboratory and basic science into the clinical practice.

Preclinical Pharmacological Evaluation

Our Featured Services

We are proud to offer powerful and reliable services for preclinical pharmacological evaluation of drugs targeting GPCRs. Browse our featured services below or use our online inquiry form to get more information.

Primary Pharmacodynamics

Primary pharmacodynamics aims to study the mode of action and/or effects of substances and their desired therapeutic targets, such enzymes and receptors. It is an important consideration for selection of appropriate preclinical animal models.

We provide both in vitro and in vivo primary pharmacodynamics services to confirm intended pharmacological effects of new drugs. Our scientists are dedicated to supporting the development of novel drugs. Their broad experience helps our customers accelerate their projects.

Secondary Pharmacodynamics

Secondary pharmacodynamics, also referred to as general pharmacology, aims to study on the mode of action and/or effects of substances not related to their desired therapeutic targets. It has an important contribution to evaluate potential adverse effects in humans.

We have extensive expertise in secondary pharmacodynamics studies. We can provide our customers with customized services and cost-effective solutions to help them save time and cost.

Safety Pharmacology

Safety pharmacology is a critical process to evaluate acute and potential effects of drugs on major organ systems and the reversibility of any characterized effects before fist-in-human testing. As a part of IND-enabling, it is required prior to the start of Phase I clinical trials.

We provide an integrated GLP and non-GLP safety pharmacology services to help de-risk your drug candidates. Our experienced expertise and high-quality data can provide valuable insights to drive your strategic decision-making process.

Pharmacokinetics and Pharmacodynamics

Pharmacokinetics (PK) and pharmacodynamics (PD) are two branches of pharmacology. PK aims to study the movement of drugs through the body, while PD aims to study the biochemical and physiological effects of drugs on the body.

We provide comprehensive and professional PK/PD services to characterize drug exposure, understand exposure-response relationship, assess bioavailability and bioequivalence, and assess therapeutic dosage. Our experienced and reputable scientists and overall strategic planning will greatly promote drug development lifecycle.

Our Capabilities

Numerous Therapeutic Areas All Drug Modalities
  • Cardiovascular Diseases
  • Dermatology
  • Endocrine Diseases
  • Gastroenterology
  • Genetic Diseases
  • Genitourinary Diseases
  • Hematology
  • Immunology
  • Infectious Diseases
  • Inflammation
  • Internal Diseases
  • Nephrology
  • Neurology
  • Oncology
  • Ophthalmology
  • Orthopedics
  • Otology
  • Pain
  • Psychiatry
  • Respiratory Diseases
  • Small molecules
  • Peptide/Protein Drugs
  • Antibody Drugs
  • Antimicrobial Drugs
  • Vaccines
  • Viral vectors
  • Immunotherapy
  • Gene and cell therapies
  • Nanoparticles
  • New drug modalities

CD BioSciences provides customized preclinical pharmacological evaluation services and tailored one-stop solutions in a high-quality, timely and cost-effective manner. Our experienced scientific team will work closely with our customers to help them achieve their goals.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

  1. McGonigle P & Williams M. Preclinical Pharmacology and Toxicology-Contributions to the Translational Interface. Reference Module in Biomedical Sciences, 2017.
  2. Whitebread S, et al. Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development. Drug discovery today, 2005, 10(21): 1421-1433.