GPCR Preclinical Toxicological Evaluation

For Research Use Only. Not For Clinical Use.

Creative Biolabs provides professional services and innovative technologies for preclinical toxicological evaluation to accelerate GPCR drug development.

Importance of Preclinical Toxicological Evaluation

Preclinical toxicological evaluation is an important and necessary process to test any substance as a drug on animals at various levels before clinical use in order to ensure complete human safety in each and every aspect. An important objective of preclinical toxicological evaluation is to identify toxic effect that cannot be discerned from clinical studies. This process also helps to determine starting dose and dose escalation for clinical trials. The toxicological evaluation of a new drug is generally dependent on its mode of action and experimental profile. Toxicological data must undergo an evaluation of reliability to minimize the chance of a failed clinical trial.

Figure 1. Features and comparison of different methods to assess drug toxicity. (Costa A, et al., 2014)

Our Featured Services

We are proud to offer powerful and reliable services for both in vitro and in vivo preclinical toxicological evaluation of drugs targeting GPCRs. Browse our featured services below or use our online inquiry form to get more information.

Cytotoxicity

2D models and 3D models
Screen libraries for toxic compounds

General Toxicology

Single dose toxicity and repeat dose toxicity study
Acute and chronic toxicity study

Genetic Toxicology

Gene mutation testing
Chromosome damage study

Musculoskeletal Toxicology

Bone Toxicology
Histomorphometry

Immunotoxicology

Evaluation of immune response
Immunophenotyping

Ocular Toxicology

Electroretinography
Fundus photography

Cardiovascular Toxicology

In vitro, in vivo and ex vivo cardiac models
Three-dimensional printed cardiac models

Infusion Toxicology

Intravenous as well as subcutaneous infusion studies
Target tissue dosing

Neurotoxicology

Delayed neurotoxicity study
Developmental neurotoxicity testing

Inhalation Toxicology

Inhalation delivery in rodents and nonrodents
Nose-only, head-only inhalation as well as whole-body exposure

Reproductive and Developmental Toxicology

Juvenile toxicity testing
Evaluation of embryolethality, embryotoxicity and teratogenicity

Phototoxicity

Cutaneous phototoxicity
Ocular phototoxicity
Visceral phototoxicity
In vitro phototoxicity

Toxicogenomics

Quantitative toxicogenomics assay
Bioinformatics analysis

Toxicokinetics

Non-GLP testing
GLP testing

More possibilities

Our Capabilities

All Relevant Routes of Administration	All Drug Modalities
Oral Intravenous (bolus and infusion) Inhalation/Intranasal/intratracheal Injection (subcutaneous, intramuscular, intraperitoneal) Dermal/Interdermal Intraocular / Intravitreal Intra-vaginal Intraduodenal Intrathecal/Intracerebral/Epidural	Small molecules Peptide/Protein Drugs Antibody Drugs Antimicrobial Drugs Vaccines Viral vectors Immunotherapy Gene and cell therapies Nanoparticles New drug modalities

Creative Biolabs provides customized preclinical toxicological evaluation services and tailored one-stop solutions in a high-quality, timely and cost-effective manner. Our experienced scientific team will work closely with our customers to help them achieve their goals.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

Costa A, et al. An evaluation of the latest in vitro tools for drug metabolism studies. Expert opinion on drug metabolism & toxicology, 2014, 10(1): 103-119.
Moses S, et al. Preclinical Toxicology Evaluation. Early Drug Development: Bringing a Preclinical Candidate to the Clinic, 2018, 2: 499-526.

GPCR Preclinical Toxicological Evaluation