GPCR Preclinical Toxicological Evaluation

GPCR Preclinical Toxicological Evaluation

For Research Use Only. Not For Clinical Use.

Creative Biolabs provides professional services and innovative technologies for preclinical toxicological evaluation to accelerate GPCR drug development.

Importance of Preclinical Toxicological Evaluation

Preclinical toxicological evaluation is an important and necessary process to test any substance as a drug on animals at various levels before clinical use in order to ensure complete human safety in each and every aspect. An important objective of preclinical toxicological evaluation is to identify toxic effect that cannot be discerned from clinical studies. This process also helps to determine starting dose and dose escalation for clinical trials. The toxicological evaluation of a new drug is generally dependent on its mode of action and experimental profile. Toxicological data must undergo an evaluation of reliability to minimize the chance of a failed clinical trial.

Features and comparison of different methods to assess drug toxicity.
Figure 1. Features and comparison of different methods to assess drug toxicity. (Costa A, et al., 2014)

Our Featured Services

We are proud to offer powerful and reliable services for both in vitro and in vivo preclinical toxicological evaluation of drugs targeting GPCRs. Browse our featured services below or use our online inquiry form to get more information.


  • 2D models and 3D models
  • Screen libraries for toxic compounds

General Toxicology

  • Single dose toxicity and repeat dose toxicity study
  • Acute and chronic toxicity study

Genetic Toxicology

  • Gene mutation testing
  • Chromosome damage study

Musculoskeletal Toxicology

  • Bone Toxicology
  • Histomorphometry


  • Evaluation of immune response
  • Immunophenotyping

Ocular Toxicology

  • Electroretinography
  • Fundus photography

Cardiovascular Toxicology

  • In vitro, in vivo and ex vivo cardiac models
  • Three-dimensional printed cardiac models

Infusion Toxicology

  • Intravenous as well as subcutaneous infusion studies
  • Target tissue dosing


  • Delayed neurotoxicity study
  • Developmental neurotoxicity testing

Inhalation Toxicology

  • Inhalation delivery in rodents and nonrodents
  • Nose-only, head-only inhalation as well as whole-body exposure

Reproductive and Developmental Toxicology

  • Juvenile toxicity testing
  • Evaluation of embryolethality, embryotoxicity and teratogenicity


  • Cutaneous phototoxicity
  • Ocular phototoxicity
  • Visceral phototoxicity
  • In vitro phototoxicity


  • Quantitative toxicogenomics assay
  • Bioinformatics analysis


  • Non-GLP testing
  • GLP testing

More possibilities

Our Capabilities

All Relevant Routes of Administration All Drug Modalities
  • Oral
  • Intravenous (bolus and infusion)
  • Inhalation/Intranasal/intratracheal
  • Injection (subcutaneous, intramuscular, intraperitoneal)
  • Dermal/Interdermal
  • Intraocular / Intravitreal
  • Intra-vaginal
  • Intraduodenal
  • Intrathecal/Intracerebral/Epidural
  • Small molecules
  • Peptide/Protein Drugs
  • Antibody Drugs
  • Antimicrobial Drugs
  • Vaccines
  • Viral vectors
  • Immunotherapy
  • Gene and cell therapies
  • Nanoparticles
  • New drug modalities

Creative Biolabs provides customized preclinical toxicological evaluation services and tailored one-stop solutions in a high-quality, timely and cost-effective manner. Our experienced scientific team will work closely with our customers to help them achieve their goals.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.


  1. Costa A, et al. An evaluation of the latest in vitro tools for drug metabolism studies. Expert opinion on drug metabolism & toxicology, 2014, 10(1): 103-119.
  2. Moses S, et al. Preclinical Toxicology Evaluation. Early Drug Development: Bringing a Preclinical Candidate to the Clinic, 2018, 2: 499-526.